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This study was conducted to determine, measure, and compare the qualities of life and suffering of patients diagnosed with chronic illnesses specifically Diabetes Mellitus type II, Bronchial Asthma, Cerebrovascular Accident, and Hypertension, assess the impact of chronic illnesses on patients’ lives in different aspects of well-being specifically, physical, psychological, social, spiritual, and their level of suffering and sought to identify major areas of concerns in the well-being of the different patients and to further prioritize care in the advent of understanding more who among the sample populations representing the four major chronic illnesses have poorer qualities of life and high levels of suffering. Results show that quality of life and suffering can be put as a broad range of human experiences related to one’s overall well-being. It can be explained in aspects of physical, psychological, social, spiritual well-beings, and levels of pain, financial frustrations and intra or interpersonal problems. It implies value based on subjective functioning in comparison with personal expectations and is defined by subjective experiences, states and perceptions. The diseases do not just vary according to their manifestations but also on the effects they have on patients. CVA patients experience more fatigue, appetite, sleep and weight changes, and suffer for longer periods with the handicaps brought about by the disease. Furthermore, stroke affects their interpersonal relationships as they tend to withdraw from society, employment is also very much affected. Spirituality tends to increase as faiths are questioned and tested. The results of this study generally show that for populations with chronic disease, measurement of QOL provides a meaningful way to determine its effect on health care provision. Researchers have concluded that qualities of life and suffering can be very subjective as individuals cope in different manners to the chronicity of the illness.